49ers Lose McCaffrey and Mason to Injuries, Struggling in NFC West

The San Francisco 49ers announced that running back Christian McCaffrey will miss the rest of the regular season due to a PCL injury, joining backup Jordan Mason on injured reserve. This adds to the team's injury woes as they sit in last place in the NFC West with a 5-7 record. McCaffrey's absence, following previous Achilles tendon issues earlier in the season, leaves rookie Isaac Guerendo as the lead back. The 49ers will need to rally for a playoff push amid these setbacks and have faced difficulties maintaining their running game.